7 edition of Anticancer Drug Toxicity found in the catalog.
April 15, 1999
by Informa Healthcare
Written in English
|The Physical Object|
|Number of Pages||558|
cytotoxic compounds where ORR and/or toxicity may not serve this purpose. A very large number of anti -cancer compounds have been and currently are under development. Only a minority, however, have completed the clinical development and obtained a marketing authorisation, due to poor activity or evidence of a detrimental safety profile. Author: William B. Pratt,William D. Ensminger,Raymond W. Ruddon. Publisher: Oxford University Press, USA ISBN: Category: Medical Page: View: DOWNLOAD → This text offers an up-to-date review of the field of cancer chemotherapy, including some of the new approaches to biological treatments of cancer and potential targets for new drug design.
INTRODUCTION. Most anticancer agents have a steep dose response relationship and a narrow therapeutic index. Small variations in the administered dose can lead to severe and life-threatening toxicity in some individuals and underdosing in . Drug toxicity and withdrawal commonly cause anxiety. Table 1 lists a number of drugs that may cause anxiety. Urine toxicology may reveal the presence of anxiogenic stimulants, such as cocaine and amphetamines. Patients with underlying anxiety disorders may be particularly sensitive to the activating effects of caffeine use, and caffeine abstinence in chronic users may produce anxiety.
Anticancer Treatments and Cardiotoxicity: Mechanisms, Diagnostic and Therapeutic Interventions presents cutting edge research on the adverse cardiac effects of both radiotherapy and chemotherapy, brought together by leaders in the field. Cancer treatment-related cardiotoxicity is the leading cause of treatment-associated mortality in cancer survivors and is one of the most common post. Anticancer drugs are chemically spoken a broad group of pharmaceuticals especially designed to treat cancer. Many have been widely used for chemotherapy for decades. They are intrinsically toxic. After administration the active compound is excreted together with its metabolites because of incomplete mineralization in the human or animal body.
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Anticancer Drug Toxicity: Prevention, Management, and Clinical Pharmacokinetics: Medicine & Health Science Books @ ed by: This paper gives an overview of different toxicities of anticancer drugs and its management. [Int J Basic Clin Pharmacol ; 1(): ] Discover the world's research.
Reduction of Anticancer Drug Toxicity Pharmacologic, Biologic, Immunologic and Molecular Genetic Approaches 3rd International Symposium, Heidelberg, December ISBN: e-ISBN: DOI: /isbn This text offers an up-to-date review of the field of cancer chemotherapy, including some of the new approaches to biological treatments of cancer and potential targets for new drug design.
A detailed description of the pharmacology, mechanisms of action, toxicity, resistance mechanisms, and clinical usefulness of each class of drugs is given.2/5(1). Frontiers Books allows users to browse, free of charge, through the pages of Frontiers e-books and e-magazines or download the entire pdf.
Keywords: chemotherapy,adverse effects,Toxicity,cancer treatment,antineoplastic drugs Science Pharmacology Pharmacology of Anti-Cancer Drugs. Keywords: Anti-cancer target,discoïdin domain. Toxicity or adverse effects of anticancer drugs include the following: Bone marrow depression due to damage for the growing stem cells causes a reduction in the white blood cell, platelet, and red cell counts.
These, in turn, could cause susceptibility to Cited by: 3. In this chapter, general principles of pharmacology relevant to anticancer drugs are presented. The specific properties of the most important anticancer drugs in clinical use are reviewed, with emphasis on their structure, mechanism of action, pharmacokinetics, and toxicity.
In systemic cancer therapy, it is common to combine several drugs. Anticancer Treatments and Cardiotoxicity is an essential reference for those involved in the research and treatment of cardiovascular toxicity. Show less Anticancer Treatments Anticancer Drug Toxicity book Cardiotoxicity: Mechanisms, Diagnostic and Therapeutic Interventions presents cutting edge research on the adverse cardiac effects of both radiotherapy and.
Mitochondrial dysfunction often underlies drug-induced toxicity and the works published over the last years point out that some of the severe adverse effects promoted by anticancer agents involve the targeting of mitochondria .
The heart, the kidneys, and the central nervous system, which have high energetic demands and are heavily. Toxicity is a major concern for anticancer drugs. These compounds present a narrow therapeutic index, with a small difference between the dose required for an antitumor effect and that responsible for unacceptable toxicity.
Their recommended doses are determined according to the toxicity endpoint. Moreover, toxicity is observed earlier than the therapeutic effect, so, toxic effects represent a. 2 days ago Cancer remains a heavy health burden resulting in a high rate of mortality around the world.
The presently used anticancer drugs suffer from several shortcomings, such as drug toxicity, poor biodegradability and bioavailability, and poor water solubility and drug resistance.
Cancer is treated effectively by combination therapy whereby two or more anticancer drugs are employed.
In this environment, he said, “Many new classes of drugs are being developed, and we have powerful advanced retinal imaging systems to identify many new manifestations of drug toxicity.” With these advances, ophthalmologists need to maintain a keen awareness of toxicities, said Gaurav K.
Shah, MD, at The Retina Institute in St. Louis. Anticancer Drug Toxicity: Prevention, Management, and Clinical Pharmacokinetics the book is a valuable source of basic facts regarding common anticancer drugs.
I see the book Cited by: 1. Download The Anticancer Drugs books, This text offers an up-to-date review of the field of cancer chemotherapy, including some of the new approaches to biological treatments of cancer and potential targets for new drug design.
A detailed description of the pharmacology, mechanisms of action, toxicity, resistance mechanisms, and clinical. Vol entitled Metallo-Drugs: Development and Action of Anticancer Agents of the series Metal Ions in Life Sciences centers on biological, medicinal inorganic chemistry. The serendipitous discovery of the antitumor activity of cis-diamminodichloroplatinum(II) (cisplatin) by Barnett Rosenberg in the s is a landmark in metallodrug-based chemotherapy.
Keywords:Toxicity, transdermal delivery, laser, anticancer drugs. Abstract: When used at a high dose, many anticancer drugs produce undesirable side effects including hepatotoxicity. Transdermal delivery bypasses first-pass metabolism, allowing the use of a lower dose of drug while decreasing systemic toxicity.
Doxorubicin: an update on anticancer molecular action, toxicity and novel drug delivery systems Oktay Tacara, Pornsak Sriamornsakb,c and Crispin R. Dassa aSchool of Biomedical and Health Sciences, Victoria University, St Albans, Australia, bDepartment of Pharmaceutical Technology, and cPharmaceutical Biopolymer Group (PBiG), Faculty of Pharmacy, Silpakorn University, Nakhon.
However, most of the drugs used to treat the aforementioned diseases suffer from several pharmacological limitations such as poor pharmacokinetics, toxicity, drug resistance, poor bioavailability and water solubility. Artemisinin and its derivatives are antimalarial drugs.
However, they also exhibit anticancer and antileishmanial activity. ANTI-TOXICITY DRUGS USED IN CANCER THERAPY. TOXICITIES OF ANTI-CANCER DRUGS: 1. Toxicities of alkylating agents: All alkylating agents are myelosuppressive, pulmonary fibrosis, sterility & secondary leukemias (less common with cyclophosphamide).
In high dose, all alkylating agents cause veno-occlusive disease in liver (reversed by defibrotide). absence of such models is considered to constitute the greatest hurdle for effic ient drug development within the foreseeable future. Since chemoprotective agents and drug resistance modifiers are used as part of anticancer regimens, some guidance on these agents will also be provided in appropriate sections of this guideline.
Anti. Anticancer Drugs Ref Book:Dr SK Srivastava,Dr H L Sharma and Dr KK sharma,Dr K D Tripathi, Drugs used to prevent toxicity of Anti cancer drugs Drug Mechanism Indications Epoetin alpha and darbopoetin alpha Erythropoietin Anemia Filgrastim, peg- filgrastim G-CSF and Febrile neutropenia prophylaxis Sargramostim GM - CHF Oprelvekin IL Reduction of Anticancer Drug Toxicity: Pharmacologic, Biologic, Immunologic and Gene Therapeutic Approaches: 48 (Contributions to Oncology, Vol.
48): Medicine & Health Science Books @ In this thoroughly updated and expanded second edition of Beverly Teicher's widely used classic survey, Anticancer Drug Development Guide: Preclinical Screening, Clinical Trials, and Approval, leading cancer researchers from pharmaceutical companies, government laboratories, and academia provide a step-by-step guide to anticancer drug development from initial design through FDA approval.